Physiological reprogramming in vivo mediated by Sox4 pioneer factor activity
T. Katsuda, J. Sussman, K. Ito, A. Katznelson, S. Yuan, J. Li, A. J. Merrell, N. Takenaka, H. Cure, Q. Li, R. U. Rasool, I. A. Asangani, K. S. Zaret, B. Stanger
This study shows Sox4 initiates hepatobiliary metaplasia by first closing hepatocyte enhancers and then opening biliary enhancers in adult liver cells.
bioRxiv · Feb 14, 2023 · PreprintCell Biology