Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking
M. J. Lista, R. P. Galao, M. Ficarelli, D. Kmiec, H. Wilson, H. Winstone, E. R. Morris, H. E. Mischo, J. Wanford, R. Youle, C. Odendall, I. A. Taylor, S. J. Neil, C. Swanson
This paper identifies the extended di-KH and CUBAN domains in KHNYN as critical for its antiviral activity and interaction with ZAP, showing that the CUBAN domain regulates trafficking and abundance.
bioRxiv · Dec 22, 2021 · PreprintMicrobiology