I. A. Taylor

A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods

Multivalent interactions essential for lentiviral integrase function

This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.

Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking

This paper identifies the extended di-KH and CUBAN domains in KHNYN as critical for its antiviral activity and interaction with ZAP, showing that the CUBAN domain regulates trafficking and abundance.

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

This study shows that HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration, as hyper-stable capsid mutants were retained at the pore and failed to integrate.

Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses

This paper investigates how SIVmus Vpr interacts with CRL4DCAF1 to ubiquitylate SAMHD1, revealing structural and mechanistic insights into viral counteraction of host restriction factors.

The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability

This study shows that GTP hydrolysis speed affects GTP cap size and microtubule stability by influencing EB protein binding and regulatory hub formation.

Structure of D. melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

The paper presents the crystal structure of dARC1 and compares it to mammalian ARC and retroviral CA proteins, showing structural divergence and functional adaptation.

Btbd6-dependent Plzf recruitment to Cul3 E3 ligase complexes through BTB domain heterodimerization

This paper identifies a mechanism where Btbd6 recruits Plzf to Cul3 E3 ligase complexes through BTB domain heterodimerization, enabling Plzf ubiquitination.