Author

H. E. Scales

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:imaging· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

J. M. Brewer· 4 shared G. R. Meehan· 2 shared P. Garside· 2 shared A. Athanasiadou· 1 shared A. Craig· 1 shared A. Kadioglu· 1 shared C. Keijzer· 1 shared E. Evertsson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersImmunology

J. M. Brewer

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Author profile →

4 papers

Recent·Most cited

Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation

G. R. Meehan, U. Gunes, H. E. Scales, G. Finney, R. Deehan, S. Sintoris, A. Athanasiadou, J. M. Brewer

This study shows spermidine suppresses dendritic cell activation through eIF5A hypusination and metabolic adaptation, reducing their ability to interact with T cells.

bioRxiv · Dec 7, 2023Immunology

A discovery pipeline for identification and in vivo validation of drugs that alter T cell/ dendritic cell interaction

H. E. Scales, C. Keijzer, E. Evertsson, P. Garside, S. Delaney, J. M. Brewer

This paper develops a drug discovery pipeline to identify and validate compounds that modulate T cell/dendritic cell interactions, identifying AS703569 as a novel inhibitor.

bioRxiv · Apr 11, 2022 · PreprintImmunology

Streptococcus pneumoniae rapidly translocates from the nasopharynx through the cribriform plate to invade and inflame the dura

T. Audshasai, J. A. Coles, S. Panagiotou, S. Khandaker, H. E. Scales, M. Kjos, M. Baltazar, J. Vignau, J. M. Brewer, A. Kadioglu, M. Yang

This study shows Streptococcus pneumoniae rapidly translocates from the nose through the cribriform plate to the meninges without entering the bloodstream.

bioRxiv · Sep 28, 2021 · PreprintMicrobiology

Developing a xenograft model of human vasculature in the mouse ear pinna

G. R. Meehan, H. E. Scales, R. Osii, M. De Niz, J. C. Lawton, M. Marti, P. Garside, A. Craig, J. M. Brewer

This paper develops a xenograft model of human vasculature in the mouse ear pinna to enable intravital imaging of human blood vessel interactions and parasite infection.

bioRxiv · Oct 2, 2019Pathology