Author

G. R. Meehan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1

Frequent Co-Authors

J. M. Brewer· 3 shared H. E. Scales· 2 shared P. Garside· 2 shared A. Athanasiadou· 1 shared A. Craig· 1 shared A. D. S. Filipe· 1 shared A. Patel· 1 shared D. C. Mendonca· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

J. M. Brewer

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Author profile →

4 papers

Recent·Most cited

Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation

G. R. Meehan, U. Gunes, H. E. Scales, G. Finney, R. Deehan, S. Sintoris, A. Athanasiadou, J. M. Brewer

This study shows spermidine suppresses dendritic cell activation through eIF5A hypusination and metabolic adaptation, reducing their ability to interact with T cells.

bioRxiv · Dec 7, 2023Immunology

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

G. R. Meehan, V. Herder, J. Allan, X. Huang, K. Kerr, D. C. Mendonca, G. Ilia, D. Wright, K. Nomikou, Q. Gu, S. M. Arias, G. De Lorenzo, V. Cowton, N. Upfold, N. Palmalux, , M. Palmarini

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.

bioRxiv · Aug 1, 2023Microbiology

Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration

G. R. Meehan, I. B. McInnes, J. M. Brewer, P. Garside

This study shows that timing of antigen administration affects disease outcome in an animal model of inflammatory arthritis, with pre-challenge administration reducing pathology and post-challenge administration exacerbating it.

bioRxiv · Jan 7, 2022Immunology

Developing a xenograft model of human vasculature in the mouse ear pinna

G. R. Meehan, H. E. Scales, R. Osii, M. De Niz, J. C. Lawton, M. Marti, P. Garside, A. Craig, J. M. Brewer

This paper develops a xenograft model of human vasculature in the mouse ear pinna to enable intravital imaging of human blood vessel interactions and parasite infection.

bioRxiv · Oct 2, 2019Pathology