M. De Niz

Investigation of Trypanosoma-induced vascular damage sheds insights into Trypanosoma vivax sequestration

This study compares the vascular interactions of three Trypanosoma species, showing T. vivax sequesters in endothelium and has unique receptor expression changes.

Spatial confinement of Trypanosoma brucei in microfluidic traps provides a new tool to study free swimming parasites

This paper develops a microfluidic device to confine Trypanosoma brucei for high-resolution imaging of its motility and behavior.

The lymphatic system favours survival of a unique T. brucei population, and its invasion results in major host pathology.

This study uses intravital and ex vivo imaging to show T. brucei colonization of lymph nodes and the lymphatic system, revealing unique parasite behavior and host pathology.

Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence

This study identifies organ-specific adhesion molecules critical for Trypanosoma brucei tissue tropism and virulence by showing their role in extravasation and reservoir establishment.

Hijacking of the host cell Golgi by Plasmodium liver stage parasites

This study shows Plasmodium liver stages manipulate host cell Golgi structure to support their development.

3D imaging of undissected optically cleared Anopheles stephensi mosquitoes infected with Plasmodium parasites

This study uses 3D imaging techniques to visualize Plasmodium parasites in whole, optically cleared Anopheles stephensi mosquitoes without dissection.

Developing a xenograft model of human vasculature in the mouse ear pinna

This paper develops a xenograft model of human vasculature in the mouse ear pinna to enable intravital imaging of human blood vessel interactions and parasite infection.