Author

H. F. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

P. O'Brien· 2 shared A. aimon· 1 shared A. Carberry· 1 shared A. Dias· 1 shared A. Douangamath· 1 shared A. Keely· 1 shared A. Moberg· 1 shared A. Powell· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

P. O'Brien

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2 papers

Recent·Most cited

Multiplexed experimental strategies for fragment library screening using SPR biosensors

E. A. FitzGerald, D. Vagrys, G. Opassi, H. F. Klein, D. J. Hamilton, P. Boronat, D. Cederfelt, V. O. Talibov, M. Abramsson, A. Moberg, M. T. Lindgren, C. Holmgren, D. Dobritzsch, B. Davis, P. O'Brien, , U. H. Danielson

The paper presents multiplexed SPR biosensor strategies for fragment library screening, improving hit identification for challenging targets.

bioRxiv · Dec 23, 2020 · PreprintBiophysics

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

A. Douangamath, D. Fearon, P. Gehrtz, T. Krojer, P. Lukacik, C. D. Owen, E. Resnick, C. Strain-Damerell, A. aimon, P. Abranyi-Balogh, J. Brandao-Neto, A. Carberry, G. Davison, A. Dias, T. D. Downes, , M. A. Walsh

The paper identifies fragment hits against SARS-CoV-2 main protease using crystallography and mass spectrometry, revealing structural insights for drug design.

bioRxiv · May 27, 2020Biophysics