A. Dias

Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

The paper uses Bayesian models to show that population responses to environmental stochasticity vary widely and are driven by survival-reproduction trade-offs and aridity.

Quantitative Determination of Protein Concentration in Living Cells

The paper introduces Calmet, a method to quantitatively determine protein concentrations in living cells using fluorescence imaging and a model membrane system.

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease

This study characterizes SARS-CoV-2 NSP15 endoribonuclease, identifies its allosteric properties, and discovers new allosteric sites for inhibitor development.

A photoswitchable ligand targeting β1-adrenoceptor enables light-control of the cardiac rhythm

This paper develops a photoswitchable ligand for β1-adrenoceptor that enables light-controlled cardiac rhythm management in zebrafish larvae.

Suitable use of FRET-based Biosensors for Quantitative Detection of GPCR Activation

The paper quantifies cAMP production using a genetically encoded biosensor in living cells and shows that biosensor expression levels affect signal linearity, necessitating stable cell lines for accurate high-throughput screening.

Global trade-offs in tree functional traits

The paper quantifies global trait variation in trees, identifying two independent processes and seven key traits that capture most variation in tree form and function.

Chemical characterization; Antimicrobial and Larvicidal activity of essential oil from Callistemon citrinus (Bottle brush) leaves

This study evaluates the larvicidal and antimicrobial activity of Callistemon citrinus essential oil against mosquito vectors and common pathogens.

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

The paper identifies new chemical fragments binding to the SARS-CoV-2 Nsp3 macrodomain through crystallographic screening and computational docking, validating their binding with biophysical techniques.

Immunogenicity of novel mRNA COVID-19 vaccine MRT5500 in mice and non-human primates

This study evaluates the immunogenicity of the mRNA vaccine MRT5500 in mice and non-human primates, showing it elicits neutralizing antibodies and TH1-biased responses.

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

The paper identifies fragment hits against SARS-CoV-2 main protease using crystallography and mass spectrometry, revealing structural insights for drug design.