SNAP-tagged nanobodies enable reversible optical control of a G protein-coupled receptor via a remotely tethered photoswitchable ligand
H. Farrants, A. Acosta Ruiz, V. A. Gutzeit, D. Trauner, K. Johnsson, J. Levitz, J. Broichhagen
This paper introduces a method to reversibly control GPCR activity using photoswitchable ligands tethered via SNAP-tagged nanobodies.
bioRxiv · Feb 15, 2018Pharmacology & Toxicology