Pharmacology & ToxicologybioRxiv
SNAP-tagged nanobodies enable reversible optical control of a G protein-coupled receptor via a remotely tethered photoswitchable ligand
H. Farrants, A. Acosta Ruiz, V. A. Gutzeit…·J. Broichhagen
This paper introduces a method to reversibly control GPCR activity using photoswitchable ligands tethered via SNAP-tagged nanobodies.
DOI 10.1021/acschembio.8b00628