ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation
A. Bansal, R. Neuhaus, E. Izquierdo-Alvarez, H. Nolte, D. Vorholt, H. Feldkoetter, P. Lohneis, R. Buettner, M. Krueger, C. Pallasch, B. Schumacher
The paper shows that DNA damage in macrophages increases PD-L1 expression and phagocytic activity, suggesting a role in chemotherapy response and immune checkpoint regulation.
bioRxiv · Mar 14, 2020 · PreprintImmunology