H. Nolte

Homeostatic mitophagy scales mitochondrial networks

The paper shows homeostatic mitophagy regulates mitochondrial network size during starvation in yeast.

CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy

This study shows CLUH is essential for maintaining mitochondrial function and translation in motoneuronal axons, preventing peripheral neuropathy in mice.

Mitochondrial translocation of TFEB regulates complex I and inflammation

This study shows TFEB regulates mitochondrial complex I and inflammation through non-transcriptional mechanisms, with implications for immune pathogenesis during infection.

Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression

This study shows NME6 supplies mitochondria with ribonucleotides to support mitochondrial gene transcription and DNA maintenance, with implications for cancer and autoimmune diseases.

Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling

This study shows that impaired phosphatidic acid transport into mitochondria disrupts ER membrane homeostasis and impairs glycolytic growth and stress signaling.

ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation

The paper shows that DNA damage in macrophages increases PD-L1 expression and phagocytic activity, suggesting a role in chemotherapy response and immune checkpoint regulation.