B. Schumacher

The auxin transporter PIN1 and the cytokinin transporter AZG1 interact to regulate the root stress response

This study identifies AZG1 as a cytokinin transporter that interacts with PIN1, an auxin transporter, to regulate root system architecture in response to environmental stress.

Loss of genome maintenance accelerates podocyte damage

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption

This study shows endogenous formaldehyde disrupts cellular redox homeostasis by reacting with glutathione, and ADH5 prevents this by regenerating reduced glutathione.

ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation

The paper shows that DNA damage in macrophages increases PD-L1 expression and phagocytic activity, suggesting a role in chemotherapy response and immune checkpoint regulation.

Arabidopsis AZG2, an auxin induced putative cytokinin transporter, regulates lateral root emergence

This study identifies AtAZG2 as an auxin-induced cytokinin transporter in Arabidopsis that regulates lateral root emergence by modulating cytokinin signaling.

Activation of the endoplasmic reticulum unfolded protein response reverses an inflammation-like response to cytoplasmic DNA

The paper shows that in C. elegans, persistent cytoplasmic DNA causes tissue degeneration through impaired protein homeostasis, which can be reversed by activating the UPRER or using N-acetylglucosamine.