Transient RNA structures cause aberrant influenza virus replication and innate immune activation
H. French, E. Pitre, M. S. Oade, E. Elshina, K. Bisht, A. King, D. L. V. Bauer, A. J. W. te Velthuis
The paper shows that transient RNA structures called template loops enhance innate immune activation by influenza A virus through stalling of the RNA polymerase.
bioRxiv · Jan 25, 2022Microbiology