Author

K. Bisht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Organism:virus· 2

Frequent Co-Authors

A. J. W. te Velthuis· 3 shared E. Elshina· 2 shared E. Pitre· 2 shared H. Jalal· 2 shared M. S. Oade· 2 shared A. Crayton· 1 shared A. Deonarine· 1 shared A. Dervan· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

A. J. W. te Velthuis

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Global stress response in Pseudomonas aeruginosa upon malonate utilization

K. Bisht, M. M. Elmassry, H. al Mahmud, S. Bhattacharjee, A. Deonarine, C. Black, M. San Francisco, A. N. Hamood, C. A. Wakeman

This study investigates how Pseudomonas aeruginosa adapts to malonate as a sole carbon source, revealing global gene expression changes and phenotypic responses.

bioRxiv · Mar 26, 2024 · PreprintMicrobiology

Quantification of influenza virus mini viral RNA dynamics using Cas13

C. Lamb, E. Pitre, E. Elshina, C. Rigby, K. Bisht, M. S. Oade, H. Jalal, C. Myhrvold, A. J. W. te Velthuis

This study quantifies influenza virus mini viral RNA (mvRNA) dynamics and subcellular distribution using Cas13, revealing non-random behavior and differences between immunostimulatory and non-immunostimulatory mvRNAs.

bioRxiv · Nov 3, 2023 · PreprintMicrobiology

Phospholamban Inhibits the Cardiac Calcium Pump Through Reversing the Allosteric Enhancement of Calcium Affinity by ATP

S. R. Cleary, J. Seflova, E. E. Cho, K. Bisht, H. Khandelia, L. M. Espinoza-Fonseca, S. L. Robia

This paper investigates how phospholamban (PLB) inhibits the cardiac calcium pump SERCA by reversing ATP-induced allosteric enhancement of calcium affinity, using biochemical assays and structural analysis.

bioRxiv · Jul 20, 2023 · PreprintBiochemistry

Evolution of transient RNA structure-RNA polymerase interactions in respiratory RNA virus genomes

C. V. Rigby, K. R. Sabsay, K. Bisht, D. Eggink, H. Jalal, A. J. W. te Velthuis

The paper examines how RNA structures in influenza A viruses change during adaptation to humans, finding reduced free energy in template loops associated with increased replication efficiency.

bioRxiv · May 25, 2023 · PreprintMicrobiology

Transient RNA structures cause aberrant influenza virus replication and innate immune activation

H. French, E. Pitre, M. S. Oade, E. Elshina, K. Bisht, A. King, D. L. V. Bauer, A. J. W. te Velthuis

The paper shows that transient RNA structures called template loops enhance innate immune activation by influenza A virus through stalling of the RNA polymerase.

bioRxiv · Jan 25, 2022Microbiology

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

J. V. Graniel, K. Bisht, A. Friedman, J. White, E. Perkey, A. Vanderbeck, A. Moroz, L. J. Carrington, J. D. Brandstadter, F. Allen, A. N. Shami, P. Thomas, A. Crayton, M. Manzor, A. Mychalowych, , J. Nandakumar

This study examines the impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline, finding progressive telomere erosion and infertility without bone marrow failure.

Life Science Alliance · Oct 13, 2021Peer-reviewedCell Biology

Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator PHF19 As Marker of Aggressive Disease

M. J. Mason, C. Schinke, C. Eng, F. Towfic, F. Gruber, A. Dervan, B. S. White, A. Pratapa, Y. Guan, H. Chen, Y. Cui, B. Li, T. Yu, E. Chaibub Neto, K. Mavrommatis, , J. A. Guinney

The paper identifies PHF19 as a marker of aggressive multiple myeloma and shows a simple four-feature model performs as well as complex gene expression models.

bioRxiv · Aug 22, 2019Cancer Biology