R. Fan

A PTN-Rich MSC Subtype Promotes Cartilage Repair in End-Stage Knee Osteoarthritis

The paper identifies a PTN-rich MSC subtype that enhances cartilage repair in KOA by modulating key inflammatory and repair pathways.

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.

Impact of Memory T Cells on SARS-COV-2 Vaccine Response in Hematopoietic Stem Cell Transplant

This study evaluates SARS-CoV-2 vaccine responses in HSCT recipients, finding memory T cell defects linked to reduced T cell responses despite humoral responses.

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function

This study shows that partial Drp1 knockout enhances autophagy flux without affecting mitochondrial function, revealing a distinct protective mechanism against manganese toxicity.

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

This study develops anti-seed PNAs targeting oncomiRs 10b and 21 for GBM therapy, showing improved tumor growth inhibition and survival in mice.

Inhibiting POLQ-mediated alternative NHEJ enhances CRISPR/Cas9 mediated precise genome editing in CHO cells

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

Engineering a minimal SilkCatcher/Tag pair compatible with SpyCatcher/Tag pair for the production of native-sized spider silk

The paper engineers a new Catcher/Tag pair, SilkCatcher/Tag, compatible with SpyCatcher/Tag, enabling the production of native-sized spider silk proteins with high purity.

MLL1 regulates cytokine-driven cell migration and metastasis

This study shows MLL1 promotes cancer metastasis by regulating cytokine secretion and actin dynamics, and its inhibition reduces metastasis when combined with chemotherapy.

SARS-CoV-2 Protein Nsp2 Stimulates Translation Under Normal and Hypoxic Conditions

This study shows that SARS-CoV-2 protein Nsp2 enhances both cap- and IRES-dependent translation under normal and hypoxic conditions, particularly for mRNAs reliant on eIF4F.

Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity

The paper develops a microfluidic immuno-serology assay to analyze immune responses in patients with altered immunity, finding reduced diversity in protein cooperation and impaired antibody responses in certain groups.

White Adipose Tissue Compositional and Transcriptional Patterns with Progressive Glucose Intolerance in Persons with HIV

The paper examines compositional and transcriptional changes in subcutaneous adipose tissue of HIV-positive individuals with varying glucose intolerance, identifying shared patterns with HIV-negative diabetics.

LAG3 regulates antibody responses in a murine model of kidney transplantation

This study shows that LAG3 deficiency in mice leads to rapid rejection of kidney allografts via antibody-mediated rejection, highlighting LAG3's role in regulating anti-donor humoral immunity.

In vivo correction of cystic fibrosis mediated by PNA nanoparticles

This study demonstrates systemic gene editing using PNA nanoparticles to correct the F508del CFTR mutation in mice, showing partial CFTR function restoration and tissue-specific correction without off-target effects.

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

The paper identifies a secretory subset of multipotent hematopoietic progenitors that enhance myelopoiesis during stress and disease by amplifying myeloid cell production through cytokine secretion.

Single-cell antigen-specific activation landscape of CAR T infusion product identifies determinants of CD19 positive relapse in patients with ALL

The paper analyzes single-cell data from CAR T infusion products to identify factors associated with CD19-positive relapse in ALL patients.

Behavioural responses to video and live presentations of females reveal a dissociation between performance and motivational aspects of birdsong

The paper examines how male zebra finches respond to live and video presentations of females, finding dissociation between song motivation and performance.

Multiplexed, sequential secretion analysis of the same single cells reveals distinct effector response dynamics dependent on the initial basal state

The paper develops a microchip-based sequential secretion assay to analyze protein dynamics in single human macrophages, revealing distinct activation modes and states dependent on basal conditions.

scFTD-seq: freeze-thaw lysis based, portable approach toward high-quality distributed single-cell 3’ mRNA profiling

scFTD-seq enables high-quality single-cell 3' mRNA profiling using freeze-thaw lysis, offering a portable and flexible workflow for distributed sample processing.

Single-cell integrative analysis of CAR-T cell activation reveals a predominantly TH1/TH2 mixed response independent of differentiation

This study analyzes CAR-T cell activation at the single-cell level, finding a mixed TH1/TH2 response with GM-CSF production, independent of differentiation status.

Ex vivo dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypes

This study uses a microvasculature-on-a-chip system to analyze ex vivo dynamics of human glioblastoma cells, showing correlations with tumor heterogeneity and subtypes.

Mini viral RNAs act as innate immune agonists during influenza virus infection

This study identifies mini viral RNAs (mvRNAs) as activators of the RIG-I sensor, leading to interferon-beta expression and cytokine storm during influenza virus infection.

Vegetative compatibility groups explain variation in the virulence of Verticillium dahliae on strawberry

The paper investigates how vegetative compatibility groups (VCGs) influence virulence of Verticillium dahliae on strawberry, finding that VCGs are strongly related to virulence levels and that VdAve1-containing isolates show higher early virulence.

FGF21 regulates melanogenesis in alpaca melanocytes via ERK1/2-Mediated MITF downregulation

This study shows FGF21 reduces melanogenesis in alpaca melanocytes by activating ERK1/2 and downregulating MITF, leading to decreased melanin production.