Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics
D. Hung, P. Ma, L. L. He, A. Pironti, H. H. Laibinis, C. M. Ernst, A. L. Manson, R. P. Bhattacharyya, A. Earl, J. Livny
This study identifies genetic factors that facilitate the evolution of carbapenem resistance in Klebsiella pneumoniae, highlighting transposon mutagenesis and mutation spectra as key contributors to resistance development.
bioRxiv · Feb 11, 2021Evolutionary Biology