Author

R. P. Bhattacharyya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Research Focus:differential expression· 5 Approach:experimental assay· 5 Organism:human· 4 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3

Frequent Co-Authors

D. T. Hung· 3 shared P. Ma· 3 shared A. L. Manson· 2 shared A. Sonny· 2 shared J. Livny· 2 shared K. R. Kays· 2 shared L. L. He· 2 shared M. A. Martinsen· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

D. T. Hung

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales

A. J. Cartagena, K. L. Taylor, L. C. Lopez, J. Su, J. T. Smith, A. L. Manson, J. D. Chen, V. M. Pierce, A. M. Earl, R. P. Bhattacharyya

This study shows that carbapenemase-producing CRE exhibit an inoculum effect, which can mislead susceptibility testing and highlights the need for improved detection methods.

bioRxiv · May 23, 2023 · PreprintMicrobiology

Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients

T. J. LaSalle, A. L. K. Gonye, S. S. Freeman, P. Kaplonek, I. Gushterova, K. R. Kays, K. Manakongtreecheep, J. Tantivit, M. Rojas-Lopez, B. C. Russo, N. Sharma, M. F. Thomas, K. M. Lavin-Parsons, B. M. Lilly, B. N. Mckaig, , M. Sade-Feldman

This study identifies distinct neutrophil phenotypes linked to disease severity in hospitalized COVID-19 patients using longitudinal data and multi-omics analyses.

Cell Reports Medicine · Oct 1, 2022Peer-reviewedImmunology

Bacterial droplet-based single-cell RNA-seq reveals heterogeneity in bacterial populations and in response to antibiotic perturbation

P. Ma, H. M. Amemiya, L. L. He, S. J. Gandhi, R. Nicol, R. P. Bhattacharyya, C. S. Smillie, D. T. Hung

BacDrop enables single-cell RNA-seq of bacteria, revealing population heterogeneity and differential responses to antibiotics in Klebsiella pneumoniae.

bioRxiv · Aug 1, 2022 · PreprintMicrobiology

A novel rRNA hybridization-based approach to rapid, accurate Candida identification directly from blood culture

M. E. Matzko, P. C. S. Sephton-Clark, E. L. Young, T. A. Jhaveri, M. A. Martinsen, E. Mojica, R. Boykin, V. M. Pierce, C. A. Cuomo, R. P. Bhattacharyya

This paper introduces a rapid, accurate method for identifying Candida species directly from blood cultures with 100% accuracy in both reference and validation panels.

bioRxiv · May 9, 2022Microbiology

Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays

S. G. Thakku, C. M. Ackerman, C. Myhrvold, R. P. Bhattacharyya, J. Livny, P. Ma, G. I. Gomez, P. Sabeti, P. C. Blainey, D. T. Hung

This paper introduces bCARMEN, a high-throughput system for rapid, multiplexed bacterial pathogen detection and antibiotic resistance gene identification using CRISPR-Cas13 and droplet microfluidics.

bioRxiv · Nov 12, 2021Microbiology

Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics

D. Hung, P. Ma, L. L. He, A. Pironti, H. H. Laibinis, C. M. Ernst, A. L. Manson, R. P. Bhattacharyya, A. Earl, J. Livny

This study identifies genetic factors that facilitate the evolution of carbapenem resistance in Klebsiella pneumoniae, highlighting transposon mutagenesis and mutation spectra as key contributors to resistance development.

bioRxiv · Feb 11, 2021Evolutionary Biology

Core Antibiotic-Induced Transcriptional Signatures Reflect Susceptibility to All Members of an Antibiotic Class

M. A. Martinsen, A. Jaramillo Cartagena, R. P. Bhattacharyya

The paper identifies 10 transcripts that reflect antibiotic susceptibility across classes, enabling faster and more efficient antibiotic testing.

bioRxiv · Oct 29, 2020Microbiology

Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19

M. Reyes, M. R. Filbin, R. P. Bhattacharyya, A. Sonny, A. Mehta, K. Billman, K. R. Kays, M. Pinilla-Vera, M. E. Benson, MGH COVID-19 Collection & Processing Team, L. A. Cosimi, D. T. Hung, B. D. Levy, A.-C. Villani, M. Sade-Feldman, , N. Hacohen

The paper identifies a regulatory myeloid program, MS1, associated with sepsis mortality and up-regulated in severe COVID-19, showing its immunosuppressive role and cytokine-dependent induction.

bioRxiv · Sep 2, 2020Immunology

Impact of population structure in the design of RNA-based diagnostics for antibiotic resistance in Neisseria gonorrhoeae

C. B. Wadsworth, M. R. A. Sater, R. P. Bhattacharyya, Y. H. Grad

This study evaluates RNA-based diagnostics for antibiotic resistance in Neisseria gonorrhoeae, finding that population structure affects transcriptional responses and identifying candidate transcripts for azithromycin resistance.

bioRxiv · Jan 31, 2019Microbiology