Author

H. Harz

Ludwig-Maximilians-Universität München

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H. Leonhardt· 4 shared C. Steinek· 2 shared D. Hoerl· 2 shared G. Stumberger· 2 shared K. Brandstetter· 2 shared A. Dolnik· 1 shared A. J. Toelke· 1 shared A. Maiser· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCell Biology

H. Leonhardt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing

Inês J. de Castro, L. Schuster, Cristian Patino Gomez, Dunja Glavaš, Arjun Udupa, Mariana Rios Vazquez, Tjardo Symens, Gabriel Tulcan, J Heinze, Heras J de las, Robert Reinhardt, Jorge Trojanowski, H. Harz, G. Stumberger, H. Leonhardt, , M. Lusic

This study identifies Nup153 as a docking point for splicing machinery at the nuclear pore, showing its role in mRNA processing and gene splicing.

bioRxiv · Sep 30, 2024 · PreprintCell Biology

Generation of densely labeled oligonucleotides for the detection of small genomic elements

C. Steinek, M. Guirao Ortiz, G. Stumberger, A. J. Toelke, D. Hoerl, T. Carell, H. Harz, H. Leonhardt

This paper introduces a method to generate densely labeled oligonucleotides for detecting small genomic elements using FISH in single cells.

bioRxiv · Mar 15, 2024Cell Biology

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

D. Weichenhan, A. Riedel, E. Sollier, U. H. Toprak, J. Hey, K. Breuer, J. A. Wierzbinska, A. Touzart, P. Lutsik, M. Baehr, A. Oestlund, C. Nilsson, S. Jacobsson, M. Edler, A. Waraky, , C. Plass

The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.

bioRxiv · Sep 13, 2023 · PreprintCancer Biology

Differences in nanoscale organization of DNase I hypersensitive and insensitive chromatin in single human cells

K. Brandstetter, T. Zuelske, T. Ragoczy, D. Hoerl, E. Haugen, E. Rynes, J. A. Stamatoyannopoulos, H. Leonhardt, G. Wedemann, H. Harz

The paper uses microscopy and modeling to study nanoscale chromatin organization in human cells, finding cell-to-cell differences in both active and inactive regions.

bioRxiv · May 27, 2021 · PreprintCell Biology

Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

M. Cremer, K. Brandstetter, A. Maiser, S. S. Rao, V. Schmid, M. Guirao-Ortiz, N. Mitra, S. Mamberti, K. N. Klein, D. M. Gilbert, H. Leonhardt, M. C. Cardoso, E. Lieberman Aiden, H. Harz, T. Cremer

The paper shows cohesin-depleted cells undergo endomitosis and rebuild a multilobulated nucleus with functional compartments despite lacking cohesin.

bioRxiv · Sep 14, 2020Cell Biology