Author

V. Mizrahi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:drug response / drug discovery· 5 Research Focus:cell type annotation· 4 Organism:bacteria (other)· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

D. F. Warner· 7 shared T. J. de Wet· 3 shared A. G. Coyne· 2 shared A. S. Koch· 2 shared C. Abell· 2 shared C. E. Barry· 2 shared C. O. Omollo· 2 shared C. Spry· 2 shared

Activity by Year

2020-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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7 shared papersMicrobiology

D. F. Warner

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

The mycobacterial mutasome: composition and recruitment in live cells

S. Gessner, Z. A.-M. Martin, M. A. Reiche, J. Santos, N. Dhar, R. Dinkele, T. J. de Wet, A. Ramudzuli, S. Anoosheh, D. M. Lang, J. Aaron, T. L. Chew, J. Herrmann, R. Mueller, J. D. McKinney, , D. F. Warner

This study identifies the molecular composition and function of the mycobacterial mutasome, showing that the ImuB-{beta} clamp interaction is essential for mutagenic DNA repair in mycobacteria.

bioRxiv · Nov 16, 2021Microbiology

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini, R. Tassoni, G. L. Abrahams, S. Lynch, Y.-M. Ahn, J. Ambler, K. Young, B. M. Crowley, D. B. Olsen, D. F. Warner, C. E. Barry, H. I. M. Boshoff, M. Lamers, V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

bioRxiv · Oct 27, 2021Microbiology

RNase HI depletion strongly potentiates cell killing by rifampicin in mycobacteria

A. Al-Zubaidi, C.-Y. Cheung, G. M. Cook, G. Taiaroa, V. Mizrahi, J. S. Lott, S. S. Dawes

This paper shows that reducing RNase HI activity in mycobacteria increases sensitivity to rifampicin, suggesting RNase HI as a target for new antibiotics.

bioRxiv · Jul 14, 2021Microbiology

Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria

D. A. Barr, C. O. Omollo, M. Mason, A. Koch, R. J. Wilkinson, D. G. Lalloo, G. Meintjes, V. Mizrahi, D. F. Warner, G. R. Davies

This paper develops a flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria, showing it can detect cell aggregates and reveal subpopulation dynamics not captured by traditional CFU counting.

bioRxiv · May 1, 2021Microbiology

Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis bioaerosols

R. Dinkele, S. Gessner, A. S. Koch, C. Morrow, M. Gqada, M. Kamariza, C. Bertozzi, B. Smith, C. McLoud, A. Kamholz, W. Bryden, C. Call, V. Mizrahi, R. Wood, D. F. Warner

This study develops a device to capture and detect live Mycobacterium tuberculosis in bioaerosols, showing high detection rates and suggesting aerosol sources differ from sputum.

PLOS Pathogens · Feb 1, 2021Peer-reviewedMicrobiology

Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis

C. O. Omollo, V. Singh, E. Kigondu, A. Wasuna, P. Agarwal, A. Moosa, T. R. Ioerger, V. Mizrahi, K. Chibale, D. F. Warner

bioRxiv · Dec 8, 2020Microbiology

De novo cobalamin biosynthesis, transport and assimilation and cobalamin-mediated regulation of methionine biosynthesis in Mycobacterium smegmatis

T. Kipkorir, G. T. Mashabela, T. J. de Wet, A. S. Koch, L. Wiesner, V. Mizrahi, D. F. Warner

This study investigates cobalamin biosynthesis, transport, and its role in methionine biosynthesis in M. smegmatis, revealing cobalamin-dependent regulation of methionine synthase expression.

bioRxiv · Nov 4, 2020Microbiology

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

J. El Bakali, M. Blaszczyk, J. C. Evans, J. A. Boland, W. J. McCarthy, M. V. B. Dias, A. G. Coyne, V. Mizrahi, T. L. Blundell, C. Abell, C. Spry

This study identifies inhibitors of MtbPPAT, a key enzyme in CoA biosynthesis, using fragment linking and CRISPR interference to validate it as a potential anti-TB drug target.

bioRxiv · Sep 4, 2020Biochemistry

Arrayed CRISPRi and Quantitative Imaging Describe the Morphotypic Landscape of Essential Mycobacterial Genes

T. J. de Wet, K. R. Winkler, M. M. Mhlanga, V. Mizrahi, D. F. Warner

The paper uses CRISPRi and imaging to analyze morphological changes in M. smegmatis, revealing gene function clusters and a new restriction-modification system.

bioRxiv · Mar 20, 2020Microbiology

Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site.

V. Mendes, S. R. Green, J. C. Evans, J. Hess, M. Blaszczyk, C. Spry, O. Bryant, J. Cory-Wright, D. S.-H. Chan, P. H. M. Torres, Z. Wang, S. O'Neill, S. Damerow, J. Post, T. Bayliss, , T. L. Blundell

The paper identifies potent inhibitors of Mycobacterium tuberculosis CoaB by targeting a novel allosteric site, based on structural and biochemical analyses of CoaBC.

bioRxiv · Jan 15, 2020 · PreprintBiochemistry