Author

A. Borsellini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. Lamers· 2 shared A. Graziadei· 1 shared A. Mazouzi· 1 shared A. Musacchio· 1 shared A. Perrakis· 1 shared A. Vannini· 1 shared B. M. Crowley· 1 shared B. Rowland· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

M. Lamers

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Condensin II activation by M18BP1

A. Borsellini, D. Conti, E. Cutts, R. J. Harris, K. Walstein, A. Graziadei, V. Cecatiello, T. F. Aarts, R. Xie, A. Mazouzi, S. Sen, C. Hoencamp, R. Pleuger, S. Ghetti, L. Oberste-Lehn, , A. Vannini

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

bioRxiv · May 2, 2024Cell Biology

A four-point molecular handover during Okazaki maturation

M. Botto, A. Borsellini, M. Lamers

The paper reveals a four-point molecular handover mechanism during Okazaki fragment maturation in E. coli, showing how DNA polymerases, endonuclease, and ligase coordinate to remove RNA primers.

bioRxiv · Aug 2, 2022Biochemistry

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini, R. Tassoni, G. L. Abrahams, S. Lynch, Y.-M. Ahn, J. Ambler, K. Young, B. M. Crowley, D. B. Olsen, D. F. Warner, C. E. Barry, H. I. M. Boshoff, M. Lamers, V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

bioRxiv · Oct 27, 2021Microbiology

Cryo-EM structures reveal how ATP and DNA binding in MutS coordinate the sequential steps of DNA mismatch repair

A. Borsellini, V. Kunetsky, P. Friedhoff, M. H. Lamers

The paper presents cryo-EM structures of Escherichia coli MutS at different stages of the ATP hydrolysis cycle, revealing how ATP binding and hydrolysis induce conformational changes that coordinate DNA mismatch repair.

bioRxiv · Jun 3, 2021Biochemistry