J. C. Evans

Triggered Release from Thermosensitive Liposomes Improves Tumor Targeting of Vinorelbine

This study evaluates thermosensitive liposomes with vinorelbine and mild hyperthermia for improved tumor targeting in a murine rhabdomyosarcoma model, showing enhanced therapeutic index.

Folate receptor targeted nanoparticles containing niraparib and doxorubicin for treatment of high grade serous ovarian cancer

This paper demonstrates the synergistic potential of niraparib and doxorubicin in ovarian cancer treatment and develops folate receptor-targeted nanoparticles for their delivery.

Group size and modularity interact to shape the spread of infection and information through animal societies

This study uses simulations to show that modular social networks can promote information spread over disease spread, especially in small groups and fragmented networks.

Family dynamics reveal that female house mice preferentially breed in their maternal community

The paper investigates female house mice breeding preferences, finding most prefer natal groups, with maternal presence influencing breeding timing but not success.

Quantifying the influence of space on social group structure

The paper introduces a method to quantify the relationship between social and spatial structure in animal groups and applies it to both simulated and empirical data.

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

This study identifies inhibitors of MtbPPAT, a key enzyme in CoA biosynthesis, using fragment linking and CRISPR interference to validate it as a potential anti-TB drug target.

Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site.

The paper identifies potent inhibitors of Mycobacterium tuberculosis CoaB by targeting a novel allosteric site, based on structural and biochemical analyses of CoaBC.