Author

S. E. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. G. Coyne· 2 shared C. Abell· 2 shared P. Gupta· 2 shared T. L. Blundell· 2 shared V. Mendes· 2 shared A. Burgess· 1 shared A. J. Whitehouse· 1 shared C. Meghir· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

A. G. Coyne

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2 papers

Recent·Most cited

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.

P. Gupta, S. E. Thomas, J. Cory-Wright, V. Sebastián-Pérez, A. Burgess, E. Cattermole, C. Meghir, C. Abell, A. G. Coyne, W. R. Jacobs, T. L. Blundell, S. Tiwari, V. Mendes

This study uses a fragment-based approach to assess the ligandability of four enzymes in the L-arginine biosynthesis pathway of M. tuberculosis, identifying potential drug targets.

bioRxiv · Mar 12, 2021Biochemistry

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

S. E. Thomas, A. J. Whitehouse, K. Brown, J. M. Belardinelli, R. Lahiri, M. D. J. Libardo, P. Gupta, S. Malhotra, H. I. M. Boshoff, M. Jackson, C. Abell, A. G. Coyne, T. L. Blundell, R. A. Floto, V. Mendes

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.

bioRxiv · May 19, 2019Biochemistry