Author

H. J. Knox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. K. Muthusamy· 2 shared A. L. Nichols· 2 shared B. N. Cohen· 2 shared C. H. Kim· 2 shared D. A. Dougherty· 2 shared H. A. Lester· 2 shared J. S. Marvin· 2 shared A. E. M. Blom· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

A. K. Muthusamy

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2 papers

Recent·Most cited

Three Mutations Convert the Selectivity of a Protein Sensor From Nicotinic Agonists to S-Methadone For Use in Cells, Organelles, and Biofluids

A. K. Muthusamy, C. H. Kim, S. C. Virgil, H. J. Knox, J. S. Marvin, A. L. Nichols, B. N. Cohen, D. A. Dougherty, L. L. Looger, H. A. Lester

The paper describes a fluorescent sensor that detects S-methadone with high selectivity and sensitivity in biological samples and cells.

bioRxiv · Feb 24, 2022Bioengineering

Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands

A. L. Nichols, Z. Blumenfeld, C. Fan, L. Luebbert, A. E. M. Blom, B. N. Cohen, J. S. Marvin, P. M. Borden, C. H. Kim, A. K. Muthusamy, A. V. Shivange, H. J. Knox, H. R. Campello, J. H. Wang, D. A. Dougherty, , H. A. Lester

The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology