J. S. Marvin

iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

The paper develops iATPSnFR2, a high dynamic range fluorescent ATP sensor for real-time subcellular ATP monitoring, showing improved performance over previous versions.

An engineered biosensor enables dynamic aspartate measurements in living cells

This paper develops a GFP-based biosensor to dynamically measure aspartate levels in living cells, showing it correlates with mass spectrometry measurements and detects temporal changes in aspartate concentration.

Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model

The paper measures dynamic attractant gradients in bacteria and shows the Patlak-Keller-Segel model fails at high cell densities, proposing an improved model that accounts for cell density effects.

Three Mutations Convert the Selectivity of a Protein Sensor From Nicotinic Agonists to S-Methadone For Use in Cells, Organelles, and Biofluids

The paper describes a fluorescent sensor that detects S-methadone with high selectivity and sensitivity in biological samples and cells.

Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands

The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.

Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics

This paper describes the development of enhanced Magnets (eMags) for optogenetic control of subcellular processes without requiring concatemerization or low-temperature preincubation.

In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor

This paper develops a genetically encoded glucose sensor for in vivo imaging across multiple organisms, revealing novel glucose dynamics in neurons, astrocytes, and zebrafish.

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

The paper develops a single-wavelength genetically encoded fluorescent sensor for imaging extracellular and cytosolic ATP, demonstrating its responsiveness to relevant concentrations and specificity for ATP.