Author

A. K. Muthusamy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. L. Nichols· 2 shared B. N. Cohen· 2 shared C. H. Kim· 2 shared D. A. Dougherty· 2 shared H. A. Lester· 2 shared H. J. Knox· 2 shared J. S. Marvin· 2 shared L. D. Lavis· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

A. L. Nichols

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Three Mutations Convert the Selectivity of a Protein Sensor From Nicotinic Agonists to S-Methadone For Use in Cells, Organelles, and Biofluids

A. K. Muthusamy, C. H. Kim, S. C. Virgil, H. J. Knox, J. S. Marvin, A. L. Nichols, B. N. Cohen, D. A. Dougherty, L. L. Looger, H. A. Lester

The paper describes a fluorescent sensor that detects S-methadone with high selectivity and sensitivity in biological samples and cells.

bioRxiv · Feb 24, 2022Bioengineering

Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands

A. L. Nichols, Z. Blumenfeld, C. Fan, L. Luebbert, A. E. M. Blom, B. N. Cohen, J. S. Marvin, P. M. Borden, C. H. Kim, A. K. Muthusamy, A. V. Shivange, H. J. Knox, H. R. Campello, J. H. Wang, D. A. Dougherty, , H. A. Lester

The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology

Nuclear Microenvironments Modulate Transcription From Low-Affinity Enhancers

J. Crocker, A. Tsai, A. K. Muthusamy, L. D. Lavis, R. H. Singer, D. L. Stern

The paper shows that low-affinity enhancer binding by Ubx is efficient in nuclear microenvironments with high Ubx concentration, aided by cofactor Hth.

bioRxiv · Apr 18, 2017Cell Biology

A general method to fine-tune fluorophores for live-cell and in vivo imaging

J. B. Grimm, A. K. Muthusamy, Y. Liang, T. A. Brown, W. C. Lemon, R. Patel, R. Lu, J. J. Macklin, P. J. Keller, N. Ji, L. D. Lavis

The paper introduces a method to fine-tune fluorophores for improved brightness and photostability in live-cell and in vivo imaging.

bioRxiv · Apr 14, 2017Cell Biology