Author

D. A. Dougherty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. L. Nichols· 3 shared H. A. Lester· 3 shared A. K. Muthusamy· 2 shared B. N. Cohen· 2 shared C. H. Kim· 2 shared H. J. Knox· 2 shared J. S. Marvin· 2 shared A. E. M. Blom· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioengineering

A. L. Nichols

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

N. Haloi, S. Huang, A. L. Nichols, E. J. Fine, N. J. Friesenhahn, C. B. Marotta, D. A. Dougherty, E. Lindahl, R. J. Howard, S. L. Mayo, H. A. Lester

The paper develops a more sensitive nicotine biosensor, iNicSnFR12, capable of detecting nicotine in diluted biofluids at clinically relevant concentrations.

bioRxiv · Jan 16, 2023Bioengineering

Three Mutations Convert the Selectivity of a Protein Sensor From Nicotinic Agonists to S-Methadone For Use in Cells, Organelles, and Biofluids

A. K. Muthusamy, C. H. Kim, S. C. Virgil, H. J. Knox, J. S. Marvin, A. L. Nichols, B. N. Cohen, D. A. Dougherty, L. L. Looger, H. A. Lester

The paper describes a fluorescent sensor that detects S-methadone with high selectivity and sensitivity in biological samples and cells.

bioRxiv · Feb 24, 2022Bioengineering

Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands

A. L. Nichols, Z. Blumenfeld, C. Fan, L. Luebbert, A. E. M. Blom, B. N. Cohen, J. S. Marvin, P. M. Borden, C. H. Kim, A. K. Muthusamy, A. V. Shivange, H. J. Knox, H. R. Campello, J. H. Wang, D. A. Dougherty, , H. A. Lester

The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology