Author

H. J. Lachmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Chandra· 1 shared A. Cope· 1 shared C. Kemper· 1 shared C. Smith· 1 shared D. A. Burden· 1 shared E. Perucha· 1 shared F. Capon· 1 shared F. D. Ciccarelli· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. Chandra

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2 papers

Recent·Most cited

Cholesterol metabolism drives regulatory B cell function

J. A. Bibby, H. A. Purvis, T. Hayday, A. Chandra, K. Okkenhaug, M. Wood, H. J. Lachmann, C. Kemper, A. Cope, E. Perucha

This study shows that cholesterol metabolism, specifically through GGPP synthesis, is essential for regulatory B cell function by promoting IL-10 production and suppressing Th1 responses.

bioRxiv · Jan 3, 2020Immunology

Interleukin-36 promotes systemic Type-I IFN responses in severe psoriasis.

M. Catapano, M. Vergnano, M. Romano, S. K. Mahil, S.-E. Choon, D. A. Burden, H. S. Young, I. M. Carr, H. J. Lachmann, G. Lombardi, C. Smith, F. D. Ciccarelli, J. N. Barker, F. Capon

The paper identifies an IL-36/TLR-9/Type-I IFN axis that drives systemic inflammation in psoriasis, offering a potential therapeutic target.

bioRxiv · Dec 14, 2018 · PreprintImmunology