M. Romano

Addressing heterogeneity in direct analysis of Extracellular Vesicles and analogues using Membrane-Sensing Peptides as Pan-Affinity Probes

This paper introduces Membrane-Sensing Peptides (MSP) as universal affinity ligands for analyzing Extracellular Vesicles and analogues, demonstrating their ability to detect EV-associated epitopes in clinical samples without prior isolation.

The complement pattern recognition molecule CL-11 promotes invasion and injury of respiratory epithelial cells by SARS-CoV-2.

This study shows CL-11 promotes SARS-CoV-2 invasion and injury of respiratory epithelial cells, suggesting CL-11 blockade could limit viral pathogenicity.

Compositional profiling of extracellular vesicles/lipoproteins mixtures by AFM nanomechanical imaging

This paper introduces an AFM-based method to distinguish and quantify lipoproteins and extracellular vesicles in mixed samples using nanomechanical imaging.

Resolvin D1 and D2 reduce SARS-Cov-2-induced inflammation in cystic fibrosis macrophages

This study investigates the role of resolvin D1 and D2 in reducing SARS-CoV-2-induced inflammation in cystic fibrosis macrophages.

The DNA mimic protein BCAS0292 is involved in the regulation of virulence of Burkholderia cenocepacia

This study identifies BCAS0292 as a DNA-mimic protein in B. cenocepacia that regulates virulence and gene expression by altering DNA topology.

An engineered stable mini-protein to plug SARS-Cov2 Spikes

The paper engineers a stable mini-protein that binds to SARS-CoV-2 Spike protein's RBD to block ACE2 interaction, showing nanomolar affinity and potential as an antiviral tool.

Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA

This study identifies suramin as a potent inhibitor of HMGA2-DNA binding, showing it disrupts HMGA2 function and induces differentiation of brain tumor stem cells.

A multidisciplinary approach to a unique Palaeolithic human ichnological record from Italy (Basura Cave)

The paper presents evidence of a Palaeolithic human group's cave exploration 14,000 years ago using ichnological data to infer behavior and social dynamics.

Interleukin-36 promotes systemic Type-I IFN responses in severe psoriasis.

The paper identifies an IL-36/TLR-9/Type-I IFN axis that drives systemic inflammation in psoriasis, offering a potential therapeutic target.

Solid immersion microscopy readily and inexpensively enables 12 nm resolution on plunge-frozen cells

This paper introduces a low-cost solid immersion lens technique that achieves 12 nm resolution in cryogenic fluorescence microscopy, outperforming more expensive systems.