Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic
H. Stewart, R. Palmulli, K. H. Johansen, N. McGovern, O. M. Shehata, G. W. Carnell, H. K. Jackson, J. S. Lee, J. C. Brown, T. C. Burgoyne, J. L. Heeney, K. Okkenhaug, A. Firth, A. A. Peden, J. R. Edgar
This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.
bioRxiv · Jan 6, 2021Cell Biology