Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
L. S. Elahi, M. Condro, R. Kawaguchi, Y. Qin, A. G. Alvarado, B. Gruender, H. Stewart, T. Li, A. Lai, M. Garrett, M. Castro, P. R. Lowenstein, H. Kornblum
This study identifies de novo lipogenesis as a vulnerability in IDH1 mutant gliomas, showing that HDAC inhibition and FASN targeting reduce tumor growth and improve survival.
bioRxiv · Nov 15, 2023Cancer Biology
L. R. Heil, N. E. Damoc, T. N. Arrey, A. Pashkova, E. Denisov, J. Petzoldt, A. Peterson, C. Hsu, B. C. Searle, N. Shulman, M. Riffle, B. Connolly, B. X. MacLean, P. M. Remes, M. Senko, , M. J. MacCoss
The paper evaluates the Astral mass analyzer's performance in quantitative proteomics, showing it quantifies 5 times more peptides per unit time than existing Orbitrap mass spectrometers and detects over 5,000 plasma proteins.
bioRxiv · Jun 3, 2023 · PreprintBiochemistry
H. Stewart, D. Grinfeld, A. Giannakopulos, J. Petzoldt, T. Shanley, M. Garland, E. Denisov, A. Peterson, E. Damoc, M. Zeller, T. Arrey, A. Pashkova, S. Renuse, A. Hakimi, A. Kuehn, , C. Hock
The paper introduces a new hybrid mass spectrometer combining Orbitrap and Astral analyzers to enable faster and more sensitive high-resolution accurate mass MS/MS spectra acquisition for proteomics.
bioRxiv · Jun 2, 2023Cell Biology
C. Lefevre, G. M. Cook, A. M. Dinan, S. Torii, H. Stewart, G. Gibbons, A. S. Nicholson, L. Echavarria-Consuegra, L. W. Meredith, V. Lulla, J. C. Kenyon, I. G. Goodfellow, J. E. Deane, S. C. Graham, A. Lakatos, , N. Irigoyen
This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.
bioRxiv · Apr 20, 2023 · PreprintMicrobiology
H. Stewart, Y. Lu, S. O'Keefe, A. Valpadashi, L. D. Cruz-Zaragoza, H. A. Michel, S. K. Nguyen, G. W. Carnell, N. Lukhovitskaya, R. Milligan, I. Jungreis, V. Lulla, A. D. Davidson, D. A. Matthews, S. High, , A. E. Firth
This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.
bioRxiv · Nov 15, 2022Microbiology
K. M. Scherer, L. Mascheroni, G. W. Carnell, L. C. S. Wunderlich, S. Makarchuk, M. Brockhoff, I. Mela, A. Fernandez-Villegas, M. Barysevich, H. Stewart, M. Suau Sans, C. L. George, J. R. Lamb, G. S. Kaminski Schierle, J. L. Heeney, C. F. Kaminski
This study tracks SARS-CoV-2 structural proteins' spatiotemporal dynamics during infection, revealing nucleocapsid's early association with ER membranes and lysosome involvement in viral egress.
bioRxiv · Jun 15, 2021Microbiology
H. Stewart, R. Palmulli, K. H. Johansen, N. McGovern, O. M. Shehata, G. W. Carnell, H. K. Jackson, J. S. Lee, J. C. Brown, T. C. Burgoyne, J. L. Heeney, K. Okkenhaug, A. Firth, A. A. Peden, J. R. Edgar
This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.
bioRxiv · Jan 6, 2021Cell Biology
A.-L. Latif, A. Newcombe, S. Li, K. Gilroy, N. Robertson, X. Lei, H. Stewart, J. Cole, M. T. Terradas, L. Rishi, L. McGarry, C. McKeeve, C. Reid, W. Clark, J. Campos, , P. D. Adams
This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.
bioRxiv · Sep 16, 2020Cell Biology
H. Stewart, K. Brown, A. M. Dinan, N. Irigoyen, E. J. Snijder, A. Firth
This study analyzes the transcription and translation of equine torovirus using RNA-seq and Ribo-seq, identifying novel open reading frames and subgenomic RNA synthesis mechanisms.
bioRxiv · Apr 7, 2018Microbiology