Author

G. W. Carnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:imaging· 1

Frequent Co-Authors

J. L. Heeney· 6 shared H. Stewart· 3 shared B. Asbach· 2 shared J. R. Edgar· 2 shared M. Ferrari· 2 shared N. J. Temperton· 2 shared R. Kinsley· 2 shared R. Wagner· 2 shared

Activity by Year

2021-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersImmunology

J. L. Heeney

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

H. Stewart, Y. Lu, S. O'Keefe, A. Valpadashi, L. D. Cruz-Zaragoza, H. A. Michel, S. K. Nguyen, G. W. Carnell, N. Lukhovitskaya, R. Milligan, I. Jungreis, V. Lulla, A. D. Davidson, D. A. Matthews, S. High, , A. E. Firth

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

bioRxiv · Nov 15, 2022Microbiology

Influenza A (N1-N9) and Influenza B (B/Vic and B/Yam) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine design

K. A. S. da Costa, J. M. M. Del Rosario, M. Ferrari, S. Vishwanath, B. Asbach, R. Kinsley, R. Wagner, J. L. Heeney, G. W. Carnell, N. J. Temperton

The paper develops NA pseudotype vectors and a pELLA assay to measure neuraminidase inhibition, showing improved sensitivity over existing methods for vaccine immunogenicity assessment.

bioRxiv · Sep 19, 2021 · PreprintImmunology

The SARS-CoV-2 nucleocapsid protein associates with the replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress

K. M. Scherer, L. Mascheroni, G. W. Carnell, L. C. S. Wunderlich, S. Makarchuk, M. Brockhoff, I. Mela, A. Fernandez-Villegas, M. Barysevich, H. Stewart, M. Suau Sans, C. L. George, J. R. Lamb, G. S. Kaminski Schierle, J. L. Heeney, C. F. Kaminski

This study tracks SARS-CoV-2 structural proteins' spatiotemporal dynamics during infection, revealing nucleocapsid's early association with ER membranes and lysosome involvement in viral egress.

bioRxiv · Jun 15, 2021Microbiology

Establishment of pan-Influenza A (H1-H18) and pan-Influenza B (pre-split, Vic/Yam) Pseudotype Libraries for efficient vaccine antigen selection

J. M. Del Rosario, K. da Costa, B. Asbach, F. Ferrara, M. Ferrari, D. Wells, G. S. Mann, V. O. Ameh, C. T. Sabeta, A. C. Banyard, R. Kinsley, S. D. Scott, R. Wagner, J. L. Heeney, G. W. Carnell, N. J. Temperton

The paper develops HA pseudotype libraries for Influenza A and B to improve vaccine antigen selection and neutralization assay capabilities.

bioRxiv · May 20, 2021 · PreprintImmunology

SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses

G. W. Carnell, K. A. Ciazynska, D. A. Wells, X. Xiong, E. T. Aguinam, S. H. McLaughlin, D. Mallery, S. Ebrahimi, L. Ceron-Gutierrez, L. C. James, R. Doffinger, J. L. Heeney, J. A. G. Briggs

This study evaluates closed-state SARS-CoV-2 spike protein immunization in mice, finding it induces potent neutralizing antibodies and T-cell responses, with unique binding properties compared to standard S protein constructs.

bioRxiv · Jan 14, 2021Immunology

Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

H. Stewart, R. Palmulli, K. H. Johansen, N. McGovern, O. M. Shehata, G. W. Carnell, H. K. Jackson, J. S. Lee, J. C. Brown, T. C. Burgoyne, J. L. Heeney, K. Okkenhaug, A. Firth, A. A. Peden, J. R. Edgar

This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.

bioRxiv · Jan 6, 2021Cell Biology