Author

H. Kleine-Weber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. K. Grosskopf· 1 shared A. Kratzel· 1 shared A. S. Hahn· 1 shared B. F. Hörnich· 1 shared C. M. Rice· 1 shared C. Stahl-Hennig· 1 shared D. Hirt· 1 shared D. Todt· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

A. K. Grosskopf

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2 papers

Recent·Most cited

SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation

B. F. Hörnich, A. K. Grosskopf, S. Schlagowski, M. Tenbusch, H. Kleine-Weber, F. Neipel, C. Stahl-Hennig, A. S. Hahn

This study compares the requirements for receptor expression and proteolytic activation in SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion, revealing differences in their dependence on ACE2, TMPRSS2, and metalloproteases.

Journal of Virology · Apr 12, 2021Peer-reviewedMicrobiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

S. Pfaender, K. B. Mar, E. Michailidis, A. Kratzel, D. Hirt, P. V'kovski, W. Fan, N. Ebert, H. Stalder, H. Kleine-Weber, M. Hoffmann, H. H. Hoffmann, M. Saeed, R. Dijkman, E. Steinmann, , V. Thiel

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

Nature Microbiology · Jul 23, 2020Peer-reviewedMicrobiology