Author

H. Stalder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Organism:human· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. Dijkman· 9 shared N. Ebert· 8 shared V. Thiel· 8 shared J. Portmann· 7 shared A. Kratzel· 6 shared P. V'kovski· 5 shared S. Steiner· 5 shared L. Laloli· 4 shared

Activity by Year

2018-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersMicrobiology

R. Dijkman

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9 papers

Recent·Most cited

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

T. Barut, N. J. Halwe, A. Taddeo, J. N. Kelly, J. Schön, N. Ebert, L. Ulrich, C. Devisme, S. Steiner, B. S. Trueeb, B. Hoffmann, I. B. Veiga, N. F. G. Leborgne, E. A. Moreira, A. Breithaupt, , V. Thiel

This study shows the spike gene determines replication, pathogenicity, and immune evasion of SARS-CoV-2 Omicron-BA.1 compared to Delta in cell cultures and animal models.

bioRxiv · Apr 28, 2022Microbiology

Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus

M. Gultom, A. Kratzel, J. Portmann, H. Stalder, A. C. Baetzner, H. Gantenbein, C. Gurtner, N. Ebert, H. Posthaus, P. Zanolari, S. Pfaender, V. Thiel, R. Dijkman

This study establishes camelid airway epithelial cell cultures to study MERS-CoV infection and replication, showing divergent tropism and interferon inhibition.

bioRxiv · Nov 10, 2021Microbiology

Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2

M. Gultom, M. Licheri, L. Laloli, M. Wider, M. Straessle, S. Steiner, A. Kratzel, T. T. N. Thao, H. Stalder, J. Portmann, M. Holwerda, P. V'kovski, N. Ebert, N. Stokar - Regenscheit, C. Gurtner, , R. Dijkman

This study assesses the susceptibility of airway epithelial cell cultures from various animals to SARS-CoV-2, finding efficient replication only in monkey and cat models.

bioRxiv · Nov 10, 2020 · PreprintMicrobiology

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

B. Zhou, T. T. N. Thao, D. Hoffmann, A. Taddeo, N. Ebert, F. Labroussaa, A. Pohlmann, J. King, J. Portmann, N. J. Halwe, L. Ulrich, B. S. Trueb, J. N. Kelly, X. Fan, B. Hoffmann, , M. Beer

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

bioRxiv · Oct 27, 2020Microbiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

S. Pfaender, K. B. Mar, E. Michailidis, A. Kratzel, D. Hirt, P. V'kovski, W. Fan, N. Ebert, H. Stalder, H. Kleine-Weber, M. Hoffmann, H. H. Hoffmann, M. Saeed, R. Dijkman, E. Steinmann, , V. Thiel

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

Nature Microbiology · Jul 23, 2020Peer-reviewedMicrobiology

Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

P. V'kovski, M. Gultom, J. N. Kelly, S. Steiner, J. Russeil, B. Mangeat, E. Cora, J. Pezoldt, M. Holwerda, A. Kratzel, L. Laloli, M. Wider, J. Portmann, T. T. N. Thao, N. Ebert, , R. Dijkman

This study compares temperature-dependent replication and immune response dynamics of SARS-CoV-2 and SARS-CoV in human airway epithelial cells, highlighting differences in their antiviral responses and transmission efficiency.

bioRxiv · Apr 27, 2020Microbiology

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

T. T. N. Thao, F. Labroussaa, N. Ebert, P. V'kovski, H. Stalder, J. Portmann, J. Kelly, S. Steiner, M. Holwerda, A. Kratzel, M. Gultom, L. Laloli, L. Huesser, M. Wider, S. Pfaender, , V. Thiel

This paper describes a yeast-based synthetic genomics platform for rapid reconstruction of RNA viruses, including SARS-CoV-2, using synthetic DNA fragments and TAR cloning.

bioRxiv · Feb 21, 2020Microbiology

Determining the replication kinetics and cellular tropism of the ruminant-associated Influenza D virus on primary human airway epithelial cells

M. Holwerda, L. Laloli, I. Stuermer, J. Portmann, H. Stalder, R. Dijkman

This study investigates the replication and cell tropism of Influenza D virus in human airway epithelial cells, finding efficient replication and ciliated cell tropism similar to Influenza C virus.

bioRxiv · Jan 3, 2019Microbiology

Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling

P. V'kovski, M. Gerber, J. Kelly, S. Pfaender, N. Ebert, S. Braga Lagache, C. Simillion, J. Portmann, H. Stalder, V. Gaschen, R. Bruggmann, M. Stoffel, M. Heller, R. Dijkman, V. Thiel

The paper identifies host proteins near coronavirus replicase complexes using proximity-labeling and shows their roles in viral replication and host processes.

bioRxiv · Sep 14, 2018Microbiology