NADPH Oxidase 2 Derived Reactive Oxygen Species Promote CD8+ T cell Effector Function
J. Chen, C. Liu, A. Chernatynskaya, B. N. Newby, T. M. Brusko, X. Xu, N. Morgan, C. P. Santarlas, W. H. Reeves, H. M. Tse, J. W. Leiding, C. E. Mathews
This study shows that NOX2-derived reactive oxygen species are essential for CD8+ T cell effector function by promoting T-bet expression and mTOR complex 1 activation.
bioRxiv · Feb 24, 2021Immunology