Author

B. N. Newby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. E. Mathews· 3 shared J. Chen· 3 shared S. E. Stimpson· 2 shared T. M. Brusko· 2 shared A. Chernatynskaya· 1 shared A. Savinov· 1 shared C. Liu· 1 shared C. P. Santarlas· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

C. E. Mathews

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Author profile →

3 papers

Recent·Most cited

Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

L. H. Armitage, S. E. Stimpson, K. E. Santostefano, L. Sui, S. O. Ogundare, B. N. Newby, R. Castro-Gutierrez, M. K. Huber, J. P. Taylor, P. Sharma, I. Radichev, D. J. Perry, N. Fredette, A. Savinov, N. Terada, , C. E. Mathews

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

bioRxiv · May 3, 2021Immunology

NADPH Oxidase 2 Derived Reactive Oxygen Species Promote CD8+ T cell Effector Function

J. Chen, C. Liu, A. Chernatynskaya, B. N. Newby, T. M. Brusko, X. Xu, N. Morgan, C. P. Santarlas, W. H. Reeves, H. M. Tse, J. W. Leiding, C. E. Mathews

This study shows that NOX2-derived reactive oxygen species are essential for CD8+ T cell effector function by promoting T-bet expression and mTOR complex 1 activation.

bioRxiv · Feb 24, 2021Immunology

Human CD8+ T-cells Require Glycolysis to Elicit Effector Function

S. E. Stimpson, J. Chen, B. N. Newby, R. Khattri, H. D. Chapman, T. E. Angelini, M. E. Merritt, D. V. Serreze, C. E. Mathews

This study shows glycolysis is essential for CD8+ T-cell effector function, while mitochondrial respiration is not, and inhibiting glycolysis reduces autoimmunity in a diabetes model.

bioRxiv · Feb 5, 2020 · PreprintImmunology