Temporal gating of SIRT1 functions by O-GlcNAcylation prevents hyperglycemia and enables physiological transitions in liver
T. Chattopadhyay, B. Maniyadath, H. P. Bagul, A. Chakraborty, N. Shukla, S. Budnar, U. Kolthur-Seetharam
This study identifies nutrient-dependent O-GlcNAcylation of SIRT1 as a mechanism controlling hepatic metabolism and insulin signaling during fasted-to-refed transitions.
bioRxiv · Apr 2, 2019 · PreprintPhysiology