Assembly and levels of P-TEFb depend on reversiblephosphorylation of cyclinT1
F. Huang, T. N. N. Nguyen, I. Echeverria, R. Ramachandran, D. C. Cary, H. Paculova, A. Sali, A. Weiss, B. M. Peterlin, K. Fujinaga
The paper shows that P-TEFb assembly and levels depend on reversible phosphorylation of cyclinT1 by PKC and dephosphorylation by PP1, leading to P-TEFb disassembly and CycT1 degradation in quiescent and terminally differentiated cells.
bioRxiv · May 25, 2021Biochemistry