Author

K. Fujinaga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

B. M. Peterlin· 2 shared F. Huang· 2 shared A. Bugai· 1 shared A. J. Quaresma· 1 shared A. Sali· 1 shared A. Weiss· 1 shared C. C. Friedel· 1 shared C. R. Sibley· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

B. M. Peterlin

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Author profile →

3 papers

Recent·Most cited

P-TEFb is degraded by Siah1/2 in quiescent cells

F. Huang, Y. Feng, B. M. Peterlin, K. Fujinaga

This study identifies Siah1/2 as E3 ligases that degrade dissociated CycT1 in resting cells, preventing P-TEFb formation.

bioRxiv · Dec 30, 2021Biochemistry

Assembly and levels of P-TEFb depend on reversiblephosphorylation of cyclinT1

F. Huang, T. N. N. Nguyen, I. Echeverria, R. Ramachandran, D. C. Cary, H. Paculova, A. Sali, A. Weiss, B. M. Peterlin, K. Fujinaga

The paper shows that P-TEFb assembly and levels depend on reversible phosphorylation of cyclinT1 by PKC and dephosphorylation by PP1, leading to P-TEFb disassembly and CycT1 degradation in quiescent and terminally differentiated cells.

bioRxiv · May 25, 2021Biochemistry

P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress

A. Bugai, A. J. Quaresma, C. C. Friedel, V. Lenasi, C. R. Sibley, P. Kukanja, K. Fujinaga, M. Blasius, T. Hennig, J. Ule, L. Doelken, M. Barboric

This study shows RBM7 activates P-TEFb to promote cell survival during genotoxic stress by enhancing Pol II elongation and transcription of DDR genes.

bioRxiv · Aug 17, 2018Biochemistry