BiochemistrybioRxiv
Assembly and levels of P-TEFb depend on reversiblephosphorylation of cyclinT1
F. Huang, T. N. N. Nguyen, I. Echeverria…·K. Fujinaga
The paper shows that P-TEFb assembly and levels depend on reversible phosphorylation of cyclinT1 by PKC and dephosphorylation by PP1, leading to P-TEFb disassembly and CycT1 degradation in quiescent and terminally differentiated cells.
DOI 10.7554/elife.68473