H. Parthasarathy

Metformin Suppresses SARS-CoV-2 in Cell Culture

This study shows metformin inhibits SARS-CoV-2 growth in cell culture by activating AMPK, reducing viral titers by up to 99%.

Regulation of eIF2α Phosphorylation by MAPKs Influences Polysome Stability and Protein Translation

This study shows that p38 MAPK and ERK1/2 regulate polysome stability and translation through integrated stress response pathways, with dual inhibition causing significant polysome collapse.

SARS-CoV-2 Infection Causes Strong mTORC1 Inhibition and Massive Polysome Collapse

This study shows SARS-CoV-2 infection inhibits mTORC1 and causes polysome collapse, but not through eIF2 phosphorylation, and allows viral mRNA translation while suppressing host mRNA translation.

Inactivation of SARS-CoV-2 by β-propiolactone Causes Aggregation of Viral Particles and Loss of Antigenic Potential

This study examines the effects of β-propiolactone on SARS-CoV-2 inactivation, finding that higher concentrations cause protein loss, antigenic degradation, and virion aggregation.

Development of Equine Immunoglobulin Fragment F(ab')2 with High Neutralizing Capability against SARS-CoV-2

This study develops equine-derived F(ab')2 antibodies with high neutralizing capability against SARS-CoV-2, showing effectiveness against viral variants.