S. Parveen

Mutation bias alters the distribution of fitness effects of mutations

The paper tests how changing mutation bias affects the distribution of fitness effects in E. coli, finding that reversing the mutation bias increases the proportion of beneficial mutations.

Bacterial pore-forming toxin pneumolysin drives pathogenicity through shed toxin-loaded host extracellular vesicles

This study shows that pneumolysin-loaded host extracellular vesicles contribute to pneumococcal pathogenesis by inducing cytotoxicity and inflammation.

Epigenetic mediated functional reprogramming of immune cells leads to HBsAg seroconversion in Hepatitis B Virus Reactivation patients

This study identifies epigenetic changes in HBV reactivation patients that drive immune and metabolic reprogramming, leading to HBsAg seroconversion.

Methods for making and observing model lipid droplets

This paper describes methods to create and analyze model lipid droplets (mLDs) to study triglyceride metabolism through biophysical measurements.

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

This study shows that JHU083, a glutamine metabolism inhibitor, reduces Mtb growth and modulates host immunity in tuberculosis, with effects dependent on host factors.

Characterization of Plasmodium falciparum RAP domain proteins-RAP291 and RAP070, and their association with ribosomal RNAs

This study characterizes two Plasmodium falciparum RAP domain proteins, showing they bind ribosomal RNAs and associate with the MSP-1 complex, and inhibit merozoite invasion.

Regulation of eIF2α Phosphorylation by MAPKs Influences Polysome Stability and Protein Translation

This study shows that p38 MAPK and ERK1/2 regulate polysome stability and translation through integrated stress response pathways, with dual inhibition causing significant polysome collapse.

Effective host-directed therapy for tuberculosis by targeted depletion of myeloid-derived suppressor cells using a diphtheria toxin-based fusion protein

This study shows that depleting myeloid-derived suppressor cells (MDSCs) using a diphtheria toxin-based fusion protein reduces Mycobacterium tuberculosis burden in mice.

IL-4 receptor targeting as an effective immunotherapy against triple-negative breast cancer

This paper demonstrates that DABIL-4, a fusion toxin targeting IL-4R, effectively reduces TNBC tumor growth and metastasis by depleting both tumor cells and immunosuppressive cells in the tumor microenvironment.

The Effect of Previous Life Cycle Phase on the Growth Kinetics, Morphology and Antibiotic Resistance of Salmonella Typhimurium DT104 in Brain Heart Infusion and Ground Chicken Extract

This study investigates how the previous life cycle phase of Salmonella Typhimurium affects its growth kinetics, morphology, and antibiotic resistance in different media and conditions.