Elevated intracellular cAMP concentration mediates growth suppression in glioma cells
D. Safitri, H. Potter, M. Harris, I. Winfield, L. Kopanitsa, H. Y. Yeung, F. Svensson, T. Rahman, M. Harper, D. Bailey, G. Ladds
The paper shows that increasing intracellular cAMP levels via AC activation or PDE inhibition suppresses glioma cell growth, with different mechanisms depending on the PDE inhibitor used.
bioRxiv · Jul 30, 2019Pharmacology & Toxicology