Author

D. Safitri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. Ladds· 5 shared M. Harris· 4 shared D. R. Poyner· 2 shared H. Y. Yeung· 2 shared I. Winfield· 2 shared K. Barkan· 2 shared S. Carvalho· 2 shared X. Huang· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersPharmacology & Toxicology

G. Ladds

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer-Associated Mutations Enhance The Sensitivity Of The Trupath GαQ/11 System

D. Safitri, M. Harris, A. Pearce, X. Huang, M. Rosa, K. Barkan, E. Wills, M. Marti-Solano, M. Falk, G. Ladds

The paper modifies Gq and G11 biosensors to enhance sensitivity for detecting Gq/11 activation in GPCRs, including those with cancer-associated mutations.

bioRxiv · Sep 1, 2022 · PreprintPharmacology & Toxicology

RAMPs regulate signalling bias and internalisation of the GIPR

M. Harris, D. I. Mackie, J. B. Pawlak, S. Carvalho, T. T. truong, D. Safitri, H. Y. Yeung, S. Routledge, M. T. Harper, B. Al-Zaid, M. Soave, S. Al-Sabah, A. Inoue, D. R. Poyner, S. J. Hill, , G. Ladds

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

bioRxiv · Apr 8, 2021 · PreprintPharmacology & Toxicology

CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells

A. Clark, N. Mullooly, D. Safitri, M. Harris, T. de Vries, A. M. Van Den Brink, D. R. Poyner, D. Gianni, M. Wigglesworth, G. Ladds

The paper demonstrates endogenous agonist bias at the calcitonin-like receptor in primary human cardiovascular cells, showing physiological consequences through RAMP switching.

bioRxiv · Dec 21, 2020 · PreprintPharmacology & Toxicology

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

M. Wall, E. Hill, R. Huckstepp, K. Barkan, G. Deganutti, M. Leuenberger, B. Preti, I. Winfield, S. Carvalho, A. Suchankova, H. Wei, D. Safitri, X. Huang, W. Imlach, C. La Mache, , B. Frenguelli

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

bioRxiv · Apr 4, 2020Physiology

Elevated intracellular cAMP concentration mediates growth suppression in glioma cells

D. Safitri, H. Potter, M. Harris, I. Winfield, L. Kopanitsa, H. Y. Yeung, F. Svensson, T. Rahman, M. Harper, D. Bailey, G. Ladds

The paper shows that increasing intracellular cAMP levels via AC activation or PDE inhibition suppresses glioma cell growth, with different mechanisms depending on the PDE inhibitor used.

bioRxiv · Jul 30, 2019Pharmacology & Toxicology