Author

M. Harper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Paleontology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Wright· 2 shared B. K. Hayes· 2 shared J. D. Boyce· 2 shared S. McGowan· 2 shared A. Farnsworth· 1 shared D. Bailey· 1 shared D. I. Roper· 1 shared D. Safitri· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

A. Wright

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Delivery determinants of an Acinetobacter baumannii type VI secretion system bifunctional peptidoglycan hydrolase.

V. Bezkorovayna, B. K. Hayes, F. N. Gillett, A. Wright, D. I. Roper, M. Harper, S. McGowan, J. D. Boyce

This study identifies the molecular function and delivery determinants of the T6SS effector Tae17 in Acinetobacter baumannii, showing it is a bifunctional peptidoglycan hydrolase with lytic transglycosylase and amidase activities.

bioRxiv · Jun 29, 2024 · PreprintMicrobiology

Structure of a Rhs effector clade domain identifies new mechanistic insights into type VI secretion system toxin delivery.

B. K. Hayes, M. Harper, H. Venugopal, J. M. Lewis, A. Wright, J. R. Steele, D. Steer, R. B. Schittenhelm, J. D. Boyce, S. McGowan

The paper presents the structure of Tse15, a T6SS Rhs effector from Acinetobacter baumannii, revealing a novel mechanism for toxin delivery and activation involving auto-cleavage and domain interaction.

bioRxiv · Nov 18, 2023 · PreprintMicrobiology

Constraining the global niche suitability of the Eusuchia clade across the Cretaceous-Paleogene boundary.

M. Harper, A. Farnsworth, P. Valdes, P. Markwick, M. T. Stockdale

This study uses species distribution models to infer the ecological niche of crocodilian relatives across the Cretaceous-Paleogene boundary, finding a wider latitudinal range and precipitation as the key climatic factor.

bioRxiv · Dec 4, 2022 · PreprintPaleontology

Elevated intracellular cAMP concentration mediates growth suppression in glioma cells

D. Safitri, H. Potter, M. Harris, I. Winfield, L. Kopanitsa, H. Y. Yeung, F. Svensson, T. Rahman, M. Harper, D. Bailey, G. Ladds

The paper shows that increasing intracellular cAMP levels via AC activation or PDE inhibition suppresses glioma cell growth, with different mechanisms depending on the PDE inhibitor used.

bioRxiv · Jul 30, 2019Pharmacology & Toxicology