M. Harris

Fibronectin 1 is required for suture patency and dysregulated across craniosynostosis models in the mouse

This study investigates the role of Fibronectin 1 in suture patency and its dysregulation in craniosynostosis models in mice, identifying FN1 as a key regulator of calvarial growth and cell differentiation.

Moth resonant mechanics are tuned to wingbeat frequency and energetic demands.

The paper investigates how moth wingbeat frequency relates to resonant frequency and biomechanical adaptations across species.

Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan

This study examines how different amino acids at position 332 of HIV-1AD8 gp120 affect viral sensitivity to antibodies, cold exposure, and infectivity.

Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice

This study shows that improving systemic insulin sensitivity via hepatic FoxO deletion does not reduce atherosclerosis in mice and may even increase it.

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies

This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.

A structural and functional analysis of opal stop codon translational readthrough during Chikungunya Virus replication

This study investigates the role of opal stop codon translational readthrough in CHIKV replication by replacing stop codons and analyzing structural and functional effects.

Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication

This paper identifies a novel role for HCV NS5A domain I in cyclophilin-dependent genome replication, showing genotype-specific differences in Cyp interactions.

Enrichment of hard sweeps on the X chromosome compared to autosomes in six Drosophila species

The paper compares selective sweep patterns between X chromosomes and autosomes in six Drosophila species, finding increased evidence of hard sweeps on the X chromosome.

Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatment

This study identifies persistent urine metabolome alterations in T. cruzi-infected mice that are not reversed by antiparasitic treatment, suggesting urine as a potential diagnostic tool for Chagas Disease.

A novel interaction between the 5' untranslated region of the Chikungunya virus genome and Musashi RNA binding protein is essential for efficient virus genome replication.

This study identifies Musashi RNA binding proteins as essential for Chikungunya virus genome replication and suggests a potential therapeutic target.

NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles

The paper identifies NS5A domain I mutations that block HCV virus assembly and shows this effect is mediated through interaction with PKR, an antiviral pathway.

Processing of the hepatitis E virus polyprotein can be mediated by a cellular protease

This paper investigates hepatitis E virus polyprotein processing and finds that it relies on host proteases rather than viral proteases for replication.

Hepatitis E virus genome replication is independent of cyclophilins A and B

This study investigates the role of cyclophilins A and B in HEV genome replication and finds they are not essential for replication of genotype 1 or 3 HEV, though CypB silencing reduces genotype 1 replication in some cells.

Cancer-Associated Mutations Enhance The Sensitivity Of The Trupath GαQ/11 System

The paper modifies Gq and G11 biosensors to enhance sensitivity for detecting Gq/11 activation in GPCRs, including those with cancer-associated mutations.

The Ecosystem Integrity Index: a novel measure of terrestrial ecosystem integrity

This paper introduces the Ecosystem Integrity Index (EII), a global measure of terrestrial ecosystem integrity, finding that one fifth of ecosystems and one quarter of ecoregions have lost over half their integrity.

Temperature impacts on dengue incidence are nonlinear and mediated by climatic and socioeconomic factors

This study examines how temperature affects dengue incidence globally, finding nonlinear relationships influenced by climatic and socioeconomic factors.

Enrichment of hard sweeps on the X chromosome in Drosophila melanogaster

The paper finds an enrichment of hard sweeps on the X chromosome in Drosophila melanogaster compared to autosomes, supporting predictions from simulations about the effects of hemizygosity and population size.

Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand

The paper investigates differences in conformational constraints on negative strand RNA folding among positive strand RNA viruses, finding significant variation in ribozyme activity and duplex formation.

Enhancement of Chikungunya virus genome replication in mammalian cells at a sub-physiological temperature

This study shows that Chikungunya virus replicates more efficiently in mammalian cells at sub-physiological temperatures due to reduced antiviral responses and enhanced stress granule recruitment.

Intra- and extra-cellular environments contribute to the fate of HIV-1 infection

The paper develops a system to monitor HIV-1 fate and shows that both intracellular and extracellular environments in BLT humanized mice influence HIV-1 infection outcomes.

RAMPs regulate signalling bias and internalisation of the GIPR

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

Identification of host antiviral genes differentially induced by clinically diverse strains of Tick-Borne Encephalitis Virus

This study identifies host antiviral genes differentially induced by high and low pathogenicity TBEV strains in cell culture, highlighting NS5 and host responses as key factors in clinical variability.

CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells

The paper demonstrates endogenous agonist bias at the calcitonin-like receptor in primary human cardiovascular cells, showing physiological consequences through RAMP switching.

Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for dynamic inter-molecular interactions involved in viral genome replication

This study identifies higher-order structures of the foot-and-mouth disease virus RdRp and their role in RNA replication through cryo-EM and mutagenesis.

Single-cell analysis reveals mechanisms of plasticity of leukemia initiating cells

The paper uses single-cell transcriptomics to show that leukemia initiating cells can convert between states, with MYC-driven oxidative phosphorylation controlling this plasticity.

Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign

The paper identifies that multiple nodular consolidation signs on CT scans are more prevalent in multidrug-resistant and extensively drug-resistant pulmonary tuberculosis compared to drug-sensitive cases.

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

The paper designs a rationally derived inhibitor of HCV p7 channel activity, revealing its dual role in virus entry and infection spread, and highlights its potential for bimodal antiviral therapy.

The Chikungunya virus nsP3 macro domain inhibits activation of the NF-κB pathway

This study shows that the CHIKV nsP3 macro domain inhibits NF-κB activation by blocking TNF-mediated signaling, with effects dependent on ADP-ribosyl hydrolase activity.

Elevated intracellular cAMP concentration mediates growth suppression in glioma cells

The paper shows that increasing intracellular cAMP levels via AC activation or PDE inhibition suppresses glioma cell growth, with different mechanisms depending on the PDE inhibitor used.

Continent-scale phenotype mapping using photographs from citizen scientists

This paper develops a method to quantify phenotypes from citizen scientists' photographs and applies it to study geographical and temporal variation in two damselfly species.