A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
T. K. Leslie, A. Tripp, A. D. James, S. P. Fraser, M. Nelson, N. Sajjaboontawee, M. S. Toss, W. Fadhil, S. C. Salvage, M. Arias Garcia, M. Beykou, E. Rakha, V. Speirs, C. Bakal, G. Poulogiannis, , W. J. Brackenbury
This study identifies a Nav1.5-dependent feedback loop that links extracellular acidification to Na+ influx, promoting breast cancer metastasis.
bioRxiv · Jun 16, 2023Cancer Biology