Author

T. K. Leslie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

W. J. Brackenbury· 3 shared A. D. James· 2 shared S. Chawla· 2 shared A. Holding· 1 shared A. J. Kennerley· 1 shared A. P. Jackson· 1 shared A. Tripp· 1 shared C. Bakal· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

W. J. Brackenbury

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Author profile →

3 papers

Recent·Most cited

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

T. K. Leslie, A. Tripp, A. D. James, S. P. Fraser, M. Nelson, N. Sajjaboontawee, M. S. Toss, W. Fadhil, S. C. Salvage, M. Arias Garcia, M. Beykou, E. Rakha, V. Speirs, C. Bakal, G. Poulogiannis, , W. J. Brackenbury

This study identifies a Nav1.5-dependent feedback loop that links extracellular acidification to Na+ influx, promoting breast cancer metastasis.

bioRxiv · Jun 16, 2023Cancer Biology

Sodium accumulation in breast cancer predicts malignancy and treatment response

A. D. James, T. K. Leslie, J. D. Kaggie, L. Wiggins, L. Patten, J. M. O'Duinn, S. Langer, M.-C. Labarthe, F. Riemer, G. Baxter, M. A. McLean, F. J. Gilbert, A. J. Kennerley, W. J. Brackenbury

This study uses 23Na MRI to show elevated sodium levels in breast tumors, which correlate with malignancy and treatment response, offering a non-invasive biomarker.

bioRxiv · Apr 14, 2021Cancer Biology

Inhibitory effect of eslicarbazepine acetate and S-licarbazepine on Nav1.5 channels

T. K. Leslie, L. Bruckner, S. Chawla, W. J. Brackenbury

This study shows that eslicarbazepine acetate and S-licarbazepine inhibit Nav1.5 channels, potentially explaining prolonged PR intervals and suggesting possible anti-invasion effects in cancer.

bioRxiv · Apr 24, 2020Pharmacology & Toxicology