This study shows EHD2 overexpression promotes tumorigenesis and metastasis in TNBC by enhancing store-operated calcium entry through caveolae stabilization.

bioRxiv · Jun 21, 2022Cancer Biology

RANK is an independent biomarker of poor prognosis in estrogen receptor-negative breast cancer and a therapeutic target in patient-derived xenografts

M. Ciscar, E. M. Trinidad, H. Perez-Montoyo, M. Alsaleem, M. J. Jimenez-Santos, M. Toss, A. Sanz-Moreno, A. Vethencourt, G. Perez-Chacon, A. Petit, M. T. Soler-Monso, J. Gomez-Miragaya, C. Gomez-Aleza, M. Jimenez, L. E. Dobrolecki, , E. Gonzalez-Suarez

This study shows RANK is a poor prognosis biomarker in ER-negative breast cancer and that targeting RANK improves outcomes in patient-derived xenografts.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

C. Gemma, C. Lai, A. Singh, A. Belfiore, N. Portman, H. Z. Milioli, M. Periyasamy, S. Abuelmaaty, A. J. Nicholls, C. Davies, N. R. Patel, G. Simmons, H. Fan, V. Nguyen, L. Magnani, , S. Ali

This study identifies VGLL1 as a driver of resistance to endocrine therapy in ER+ breast cancer and shows that targeting VGLL1/TEAD interaction can inhibit resistant cell growth.

bioRxiv · Nov 29, 2020Cancer Biology

Outcome of radial scar/complex sclerosing lesion associated with epithelial proliferations with atypia diagnosed on breast core biopsy - Results from a multicentric UK based study

E. Rakha, F. Beca, M. D'Andrea, A. Abbas, W. Petrou-Nunn, A. M. Shaaban, A. Kandiyil, S. Smith, S. Menon, S. Elsheikh, M. E. ElSayed, A. H. S. Lee, N. Sharma

The study evaluates the upgrade rate of radial scar/complex sclerosing lesion with atypia to malignancy on surgical excision, finding higher rates with atypical ductal hyperplasia than lobular neoplasia.

bioRxiv · Feb 4, 2019Pathology