Author

H. R. O'Donnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

B. K. Shoichet· 4 shared A. Basbaum· 2 shared B. L. Roth· 2 shared P. Lak· 2 shared T. A. Tummino· 2 shared V. Craik· 2 shared A. Alon· 1 shared A. Fischer· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiochemistry

B. K. Shoichet

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiochemistrybioRxivJun 13, 2022

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

I. Singh, A. Seth, C. B. Billesbolle…·G. Rudnick

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

DOI 10.1016/j.cell.2023.04.010

mousestructural biology

𝕏 PostBluesky

BiophysicsbioRxivPreprintDec 6, 2021

Structure-based design of a chemical probe set for the 5-HT5A serotonin receptor

A. L. Kaplan, R. T. Strachan, J. M. Braz…·B. K. Shoichet

The paper develops a more selective chemical probe set for the 5-HT5A receptor, showing improved selectivity and reduced assay liabilities compared to the existing SB-699551 antagonist.

DOI 10.1101/2021.12.06.471449

mouseexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivAug 31, 2021

Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens

H. R. O'Donnell, T. A. Tummino, C. Bardine…·B. K. Shoichet

This study identifies colloidal aggregators in SARS-CoV-2 drug repurposing screens, showing that many drugs form colloids at therapeutic concentrations, potentially leading to false positive results.

DOI 10.1021/acs.jmedchem.1c01547

experimental assay

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintMar 23, 2021

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

T. A. Tummino, V. V. Rezelj, B. Fischer…·B. K. Shoichet

DOI 10.1101/2021.03.23.436648

humanexperimental assay

𝕏 PostBluesky